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IVF BIG DATA

Embryo morphology in IVF cycles - exploratory analysis

Exploratory views over the full dataset (7,113 FET records): morphology, maternal age, biopsy day (day 5 vs day 6), and clinical pregnancy rates. These panels are not filtered by the ongoing PR calculator; they always reflect the full cohort.

Embryo morphology — frequency

Number of FET cycles per morphology Gardner grade (most frequent grades by count).
5AA
1,160
3AA
870
3AB
695
5AB
609
4AA
451
5BB
426
3BB
423
6AA
358
4AB
339
6BB
254
4BB
166
2AA
166
2AB
150
6AB
143
5BA
142
6BA
106
3BB-
86
2BB
77
3BA
73
4BA
49
6B-B
34
3B-B-
34
5BB-
33
3B-B
30
4BB-
26
5B-B
26
2BB-
23
6BB-
23
6B-B-
21
5B-B-
20
4B-B-
15
2B-B-
13
3AB-
11
5AB-
10
2BA
8
4B-B
7
2B-B
5
4AB-
4
3B-A
4
2AB-
4
2BC
2
1AB
2
5B-A
2
3AA
1
5BB
1

Embryo age — frequency

Number of FET cycles per maternal age in the dataset.
20
2
21
5
22
17
23
13
24
19
25
42
26
40
27
41
28
80
29
108
30
204
31
264
32
365
33
467
34
587
35
653
36
655
37
744
38
722
39
655
40
501
41
377
42
265
43
142
44
63
45
38
46
19
47
12
48
5
49
5
51
1
53
2

Biopsy day — frequency

Number of FET cycles by biopsy day (day 5 vs day 6 in this cohort).
Day 5 biopsy
4,193
Day 6 biopsy
2,872
Day 7 biopsy
48

Biopsy day vs Clinical PR

Clinical pregnancy rate (IUP / FET × 100%) by biopsy day. Bar length = clinical PR; n = FET cycles in each group.
0%25%50%75%100%Day 5 — 79.30% clinical PR (3325 IUP / 4193 FET)Day 579.30%n=4193Day 6 — 64.35% clinical PR (1848 IUP / 2872 FET)Day 664.35%n=2872Day 7 — 41.67% clinical PR (20 IUP / 48 FET)Day 741.67%n=48

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Morphology and maternal age

Heatmap of FET counts for the most frequent morphologies (rows) × maternal ages (columns). Darker blue = more cycles in that cell.
Morphology2021222324252627282930313233343536373839404142434445464748495153
5AA
1
1
3
3
11
9
10
17
15
40
55
66
86
106
116
116
122
103
88
70
53
36
13
7
8
3
1
1
3AA
1
1
2
4
4
7
7
27
40
57
78
82
84
85
91
102
61
63
26
18
12
9
3
2
4
3AB
2
1
1
5
8
2
7
14
25
28
32
49
48
60
70
81
63
56
53
38
26
12
7
4
1
1
1
5AB
1
2
2
1
5
4
6
10
12
14
22
30
38
37
56
49
59
74
68
43
34
26
11
2
2
1
4AA
1
1
4
2
4
5
14
15
31
33
54
51
35
42
41
40
32
18
13
8
4
2
1
5BB
3
1
4
3
1
2
4
7
5
14
21
20
33
35
34
48
36
59
30
21
21
12
4
4
2
2
3BB
1
1
1
1
3
2
3
6
9
8
14
16
17
29
31
28
31
42
37
41
35
25
20
8
9
1
1
1
1
1
6AA
1
3
2
2
3
7
11
12
20
22
34
39
30
39
30
32
28
19
7
10
4
2
1
4AB
1
1
2
1
5
6
11
15
14
18
32
25
43
35
44
28
18
16
8
7
4
3
1
1
6BB
1
1
3
2
1
3
1
4
11
8
11
9
10
19
24
24
34
25
15
20
13
9
2
2
1
1
4BB
1
1
1
2
4
1
5
11
9
14
16
13
16
22
9
9
12
8
6
1
3
1
1
2AA
1
1
1
1
2
5
11
12
20
17
18
25
12
15
7
11
4
1
1
1
2AB
1
1
3
5
7
8
14
15
17
15
17
15
9
11
7
2
2
1
6AB
1
4
1
4
14
10
12
12
17
13
22
16
7
6
3
1
5BA
2
3
2
2
3
8
8
15
18
10
11
17
13
6
10
7
3
2
1
1
6BA
1
1
3
5
5
6
8
4
9
11
9
6
9
8
7
9
3
1
1

Morphology and biopsy day

Heatmap of FET counts for the most frequent morphologies (rows) × biopsy day (columns: 5 = day 5 biopsy, 6 = day 6 biopsy). Darker blue = more cycles in that cell.
MorphologyDay 5Day 6Day 7
5AA
683
475
2
3AA
788
82
3AB
580
113
2
5AB
358
249
2
4AA
354
97
5BB
105
319
2
3BB
269
150
4
6AA
88
266
4
4AB
250
89
6BB
28
219
7
4BB
74
91
1
2AA
156
10
2AB
129
21
6AB
43
98
2
5BA
47
94
1
6BA
11
92
3

Quality of the embryos vs clinical PR

Gardner grades (expansion 1–6 + ICM + TE). Each row lists the category and a short definition below it. Bar length = clinical PR (IUP / FET × 100%). The table below splits the same quality groups by biopsy day (day 5 vs day 6).
0%25%50%75%100%Good (ICM/TE pairs AA, AB, or BA) — 76.94% clinical PR (4097 IUP / 5325 FET)GoodICM/TE pairs AA, AB, or BA76.94%n=5325Fair (ICM/TE pair BB) — 65.16% clinical PR (879 IUP / 1349 FET)FairICM/TE pair BB65.16%n=1349Borderline fair (Any B− on ICM or TE) — 49.43% clinical PR (215 IUP / 435 FET)Borderline fairAny B− on ICM or TE49.43%n=435Poor (Any C on ICM or TE) — 50.00% clinical PR (2 IUP / 4 FET)PoorAny C on ICM or TE50.00%n=4

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Same quality groups, stratified by biopsy day

Clinical PR in each cell (IUP / FET × 100%). Same PR bands as the chart above, with saturated fills: under 40% pink, 40–56% blue, 56% and above green. Empty cells had no FETs in that quality × biopsy-day combination.

QualityDay 5 biopsyDay 6 biopsyDay 7 biopsy
Good
ICM/TE pairs AA, AB, or BA
80.05%n=3,579
70.73%n=1,729
52.94%n=17
Fair
ICM/TE pair BB
76.58%n=521
58.35%n=814
35.71%n=14
Borderline fair
Any B− on ICM or TE
65.59%n=93
45.54%n=325
35.29%n=17
Poor
Any C on ICM or TE
—
50%n=4
—

Expansion grade vs Clinical PR

Gardner expansion grade (1–6) from the embryo grade. Bar length = clinical PR (IUP / FET × 100%).
0%25%50%75%100%Grade 1 — 40.00% clinical PR (2 IUP / 5 FET)Grade 140.00%n=5Grade 2 — 77.28% clinical PR (347 IUP / 449 FET)Grade 277.28%n=449Grade 3 — 75.09% clinical PR (1673 IUP / 2228 FET)Grade 375.09%n=2228Grade 4 — 75.80% clinical PR (802 IUP / 1058 FET)Grade 475.80%n=1058Grade 5 — 72.37% clinical PR (1760 IUP / 2432 FET)Grade 572.37%n=2432Grade 6 — 64.68% clinical PR (608 IUP / 940 FET)Grade 664.68%n=940

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Embryo morphology vs Clinical PR

Clinical pregnancy rate (IUP / FET × 100%) per morphology for the most frequent grades. Same layout as Clinical PR by morphology (0–100% scale, tier colors, n=).
0%25%50%75%100%5AA — 75.26% clinical PR (873 IUP / 1160 FET)5AA75.26%n=11603AA — 80.11% clinical PR (697 IUP / 870 FET)3AA80.11%n=8703AB — 77.99% clinical PR (542 IUP / 695 FET)3AB77.99%n=6955AB — 77.34% clinical PR (471 IUP / 609 FET)5AB77.34%n=6094AA — 80.04% clinical PR (361 IUP / 451 FET)4AA80.04%n=4515BB — 63.62% clinical PR (271 IUP / 426 FET)5BB63.62%n=4263BB — 70.21% clinical PR (297 IUP / 423 FET)3BB70.21%n=4236AA — 73.74% clinical PR (264 IUP / 358 FET)6AA73.74%n=3584AB — 78.17% clinical PR (265 IUP / 339 FET)4AB78.17%n=3396BB — 58.27% clinical PR (148 IUP / 254 FET)6BB58.27%n=2544BB — 66.87% clinical PR (111 IUP / 166 FET)4BB66.87%n=1662AA — 82.53% clinical PR (137 IUP / 166 FET)2AA82.53%n=1662AB — 84.00% clinical PR (126 IUP / 150 FET)2AB84.00%n=1506AB — 65.73% clinical PR (94 IUP / 143 FET)6AB65.73%n=1435BA — 70.42% clinical PR (100 IUP / 142 FET)5BA70.42%n=1426BA — 62.26% clinical PR (66 IUP / 106 FET)6BA62.26%n=1063BB- — 53.49% clinical PR (46 IUP / 86 FET)3BB-53.49%n=862BB — 64.94% clinical PR (50 IUP / 77 FET)2BB64.94%n=773BA — 76.71% clinical PR (56 IUP / 73 FET)3BA76.71%n=734BA — 73.47% clinical PR (36 IUP / 49 FET)4BA73.47%n=496B-B — 50.00% clinical PR (17 IUP / 34 FET)6B-B50.00%n=343B-B- — 26.47% clinical PR (9 IUP / 34 FET)3B-B-26.47%n=345BB- — 42.42% clinical PR (14 IUP / 33 FET)5BB-42.42%n=333B-B — 50.00% clinical PR (15 IUP / 30 FET)3B-B50.00%n=304BB- — 53.85% clinical PR (14 IUP / 26 FET)4BB-53.85%n=265B-B — 65.38% clinical PR (17 IUP / 26 FET)5B-B65.38%n=262BB- — 65.22% clinical PR (15 IUP / 23 FET)2BB-65.22%n=236BB- — 47.83% clinical PR (11 IUP / 23 FET)6BB-47.83%n=236B-B- — 38.10% clinical PR (8 IUP / 21 FET)6B-B-38.10%n=215B-B- — 30.00% clinical PR (6 IUP / 20 FET)5B-B-30.00%n=204B-B- — 60.00% clinical PR (9 IUP / 15 FET)4B-B-60.00%n=152B-B- — 46.15% clinical PR (6 IUP / 13 FET)2B-B-46.15%n=133AB- — 54.55% clinical PR (6 IUP / 11 FET)3AB-54.55%n=115AB- — 50.00% clinical PR (5 IUP / 10 FET)5AB-50.00%n=102BA — 62.50% clinical PR (5 IUP / 8 FET)2BA62.50%n=84B-B — 28.57% clinical PR (2 IUP / 7 FET)4B-B28.57%n=72B-B — 40.00% clinical PR (2 IUP / 5 FET)2B-B40.00%n=54AB- — 75.00% clinical PR (3 IUP / 4 FET)4AB-75.00%n=43B-A — 75.00% clinical PR (3 IUP / 4 FET)3B-A75.00%n=42AB- — 100.00% clinical PR (4 IUP / 4 FET)2AB-100.00%n=4

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Age vs Clinical PR

Clinical pregnancy rate by maternal age with a sample size for each age group.
0%25%50%75%100%20 — 100.00% clinical PR (2 IUP / 2 FET)20100.00%n=221 — 80.00% clinical PR (4 IUP / 5 FET)2180.00%n=522 — 58.82% clinical PR (10 IUP / 17 FET)2258.82%n=1723 — 46.15% clinical PR (6 IUP / 13 FET)2346.15%n=1324 — 52.63% clinical PR (10 IUP / 19 FET)2452.63%n=1925 — 76.19% clinical PR (32 IUP / 42 FET)2576.19%n=4226 — 65.00% clinical PR (26 IUP / 40 FET)2665.00%n=4027 — 75.61% clinical PR (31 IUP / 41 FET)2775.61%n=4128 — 78.75% clinical PR (63 IUP / 80 FET)2878.75%n=8029 — 67.59% clinical PR (73 IUP / 108 FET)2967.59%n=10830 — 71.08% clinical PR (145 IUP / 204 FET)3071.08%n=20431 — 77.65% clinical PR (205 IUP / 264 FET)3177.65%n=26432 — 78.36% clinical PR (286 IUP / 365 FET)3278.36%n=36533 — 72.59% clinical PR (339 IUP / 467 FET)3372.59%n=46734 — 77.68% clinical PR (456 IUP / 587 FET)3477.68%n=58735 — 75.34% clinical PR (492 IUP / 653 FET)3575.34%n=65336 — 73.74% clinical PR (483 IUP / 655 FET)3673.74%n=65537 — 69.89% clinical PR (520 IUP / 744 FET)3769.89%n=74438 — 72.99% clinical PR (527 IUP / 722 FET)3872.99%n=72239 — 72.82% clinical PR (477 IUP / 655 FET)3972.82%n=65540 — 71.46% clinical PR (358 IUP / 501 FET)4071.46%n=50141 — 68.97% clinical PR (260 IUP / 377 FET)4168.97%n=37742 — 67.17% clinical PR (178 IUP / 265 FET)4267.17%n=26543 — 73.94% clinical PR (105 IUP / 142 FET)4373.94%n=14244 — 71.43% clinical PR (45 IUP / 63 FET)4471.43%n=6345 — 68.42% clinical PR (26 IUP / 38 FET)4568.42%n=3846 — 68.42% clinical PR (13 IUP / 19 FET)4668.42%n=1947 — 83.33% clinical PR (10 IUP / 12 FET)4783.33%n=1248 — 100.00% clinical PR (5 IUP / 5 FET)48100.00%n=549 — 80.00% clinical PR (4 IUP / 5 FET)4980.00%n=551 — 0.00% clinical PR (0 IUP / 1 FET)510.00%n=153 — 100.00% clinical PR (2 IUP / 2 FET)53100.00%n=2

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.